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In recent years, prebiotics, probiotics, and postbiotics have garnered significant attention for their ability to improve gut health and provide various health benefits, including enhancing skin health. Let’s explore the differences between these three categories, with a special focus on the innovative and stable nature of postbiotics.



Prebiotics are non-digestible food ingredients that stimulate the growth or activity of beneficial microorganisms in the intestines. They serve as food for probiotics (the beneficial bacteria), helping them thrive. Common sources of prebiotics include:

  • Fiber-rich foods like fruits, vegetables, and whole grains
  • Inulin and fructooligosaccharides (FOS)

Prebiotics have been shown to improve gut health, enhance digestion, and boost the immune system, indirectly benefiting skin health by promoting a balanced gut microbiome.



Probiotics are live microorganisms that, when consumed in adequate amounts, confer health benefits to the host. They are commonly found in fermented foods such as yogurt, kefir, sauerkraut, and dietary supplements. Probiotics help restore the natural balance of gut bacteria, which can be disrupted by factors like antibiotics, poor diet, or illness. Benefits of probiotics include:

  • Improving digestive health
  • Enhancing the immune system
  • Reducing inflammation

Probiotics have also been linked to positive effects on various skin conditions, such as atopic dermatitis, acne, and burn injuries. They help rejuvenate the skin, improve its innate immunity, and can even be applied topically to enhance skin barrier function and antimicrobial properties.



Postbiotics are the metabolic by-products of probiotic bacterial fermentation. Unlike probiotics, postbiotics do not contain live bacteria. Instead, they include components like:

  • Antimicrobial peptides
  • Short-chain fatty acids
  • Cell wall fragments
  • Metabolites

Why Postbiotics?

  1. Stability: Postbiotics are more stable than live probiotics, making them easier to incorporate into various formulations without losing efficacy. They are not affected by storage conditions, temperature, or the acidic environment of the stomach, ensuring consistent benefits.
  2. Safety: Since postbiotics do not contain live bacteria, there is no risk of infection or complications associated with the use of live microorganisms. This makes them a safer option for individuals with compromised immune systems.
  3. Efficacy: Postbiotics provide health benefits similar to probiotics. They can improve skin hydration, elasticity, and gloss, and reduce wrinkles. Studies have shown that postbiotics can enhance skin barrier function, increase antimicrobial properties, and protect against acne and erythema.


Lactosporin: A Promising Postbiotic

One notable postbiotic is Lactosporin, an extracellular metabolite produced by the probiotic strain Bacillus coagulans MTCC 5856 (LactoSpore®). Lactosporin has demonstrated significant antimicrobial activity and has been evaluated for its efficacy against acne. It has been found safe for cosmetic use and registered under the Cosmetics Regulation (EC) No 1223/2009.

Benefits of Lactosporin:

  1. Antimicrobial Activity: Lactosporin prevents the growth of pathogenic microbes, promoting a healthier skin microbiome.
  2. Clinical Efficacy: Studies have shown its effectiveness in treating acne and improving overall skin health.
  3. Safe for Use: It has received the Generally Regarded as Safe (GRAS) status from the USFDA, ensuring its safety for consumers.


While prebiotics and probiotics have been extensively used to restore gut microbiome and improve skin health, postbiotics represent a new frontier in skincare and health. With their stability, safety, and efficacy, postbiotics like Lactosporin offer promising benefits for maintaining a healthy skin microbiome and addressing various skin conditions. Embracing this new technology could be a game-changer for skincare formulations and overall skin health.